# From bench to bedside: translational insights into aging research

**Authors:** Kanti Bhooshan Pandey

PMC · DOI: 10.3389/fragi.2025.1492099 · Frontiers in Aging · 2025-01-24

## TL;DR

This review explores how aging research is moving from basic science to real-world medical applications.

## Contribution

The paper provides translational insights that connect molecular aging research to clinical practice.

## Key findings

- Key discoveries in aging mechanisms are being translated into clinical applications.
- Biomarkers and therapeutic interventions are central to bridging bench and bedside.
- Interdisciplinary collaboration is essential for addressing aging complexities.

## Abstract

Aging research has rapidly advanced from fundamental discoveries at the molecular and cellular levels to promising clinical applications. This review discusses the critical translational insights that bridge the gap between bench research and bedside applications, highlighting key discoveries in the mechanisms of aging, biomarkers, and therapeutic interventions. It underscores the importance of interdisciplinary approaches and collaboration among scientists, clinicians, and policymakers to address the complexities of aging and improve health span.

## Full-text entities

- **Genes:** GGTLC4P (gamma-glutamyltransferase light chain 4 pseudogene) [NCBI Gene 729838] {aka GGT}, ATF3 (activating transcription factor 3) [NCBI Gene 467], STING1 (stimulator of interferon response cGAMP interactor 1) [NCBI Gene 340061] {aka ERIS, MITA, MPYS, NET23, SAVI, STING}, CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}, RB1 (RB transcriptional corepressor 1) [NCBI Gene 5925] {aka OSRC, PPP1R130, RB, p105-Rb, p110-RB1, pRb}, H3P16 (H3 histone pseudogene 16) [NCBI Gene 644914] {aka H3.6, H3F3AP6, p21}, SLC17A5 (solute carrier family 17 member 5) [NCBI Gene 26503] {aka AST, ISSD, NSD, SD, SIALIN, SIASD}, CGAS (cyclic GMP-AMP synthase) [NCBI Gene 115004] {aka C6orf150, D4, MB21D1, h-cGAS}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, ATF4 (activating transcription factor 4) [NCBI Gene 468] {aka CREB-2, CREB2, TAXREB67, TXREB}, MTOR (mechanistic target of rapamycin kinase) [NCBI Gene 2475] {aka FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS}, CDKN2A (cyclin dependent kinase inhibitor 2A) [NCBI Gene 1029] {aka ARF, CAI2, CDK4I, CDKN2, CMM2, INK4}, daf-2 (Insulin-like receptor subunit beta;Protein kinase domain-containing protein;receptor protein-tyrosine kinase) [NCBI Gene 175410], HSPA8 (heat shock protein family A (Hsp70) member 8) [NCBI Gene 3312] {aka HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71}
- **Diseases:** diabetes (MESH:D003920), cancer (MESH:D009369), cardiovascular ailments (MESH:D002318), chronic obstructive pulmonary disease (MESH:D029424), age-related degenerative conditions (MESH:D019636), neuroinflammation (MESH:D000090862), neuro-complications (MESH:D008107), heat disease (MESH:D018883), carcinogenesis (MESH:D063646), neuro-diseases (MESH:C536203), age-related diseases (MESH:D010024), organ failure (MESH:D009102), loss of function (MESH:D006315), infection (MESH:D007239), Impaired proteostasis (MESH:D057165), diseases (MESH:D004194), mitochondrial dysfunction (MESH:D028361), neurological problems (MESH:D009461), Aseptic inflammation (MESH:D007249), age-related tissue dysfunctions (MESH:D008569)
- **Chemicals:** 5-methylcytosine (MESH:D044503), lipid (MESH:D008055), TAME (-), creatinine (MESH:D003404), ascorbate (MESH:D001205), NAD+ (MESH:D009243), thiols (MESH:D013438), nicotinamide riboside (MESH:C018613), Dasatinib (MESH:D000069439), glutathione (MESH:D005978), 5-hydroxymethylcytosine (MESH:C011865), doxazosin (MESH:D017292), ROS (MESH:D017382), quercetin (MESH:D011794), Metformin (MESH:D008687), Polyphenols (MESH:D059808), Rapamycin (MESH:D020123)
- **Species:** Homo sapiens (human, species) [taxon 9606], C. elegans [taxon 328850], Drosophila melanogaster (fruit fly, species) [taxon 7227]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11802818/full.md

## References

101 references — full list in the complete paper: https://tomesphere.com/paper/PMC11802818/full.md

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Source: https://tomesphere.com/paper/PMC11802818