# Active ingredients of traditional Chinese medicine inhibit NOD-like receptor protein 3 inflammasome: a novel strategy for preventing and treating heart failure

## TL;DR

This paper explores how traditional Chinese medicine ingredients can inhibit a key protein complex linked to heart failure, offering a new treatment strategy.

## Contribution

The novelty lies in reviewing TCM active ingredients as potential inhibitors of the NLRP3 inflammasome for heart failure treatment.

## Key findings

- NLRP3 inflammasome activation is pivotal in heart failure progression.
- TCM active ingredients show promise in inhibiting NLRP3 and improving heart function.
- This approach offers a novel strategy for precise heart failure intervention.

## Abstract

Heart failure (HF) has emerged as a significant global public health challenge owing to its high rates of morbidity and mortality. Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome is regarded as a pivotal factor in the onset and progression of HF. Therefore, inhibiting the activation of the NLRP3 inflammasome may represent a promising therapeutic approach for preventing and treating HF. The active ingredients serve as the foundation for the therapeutic effects of traditional Chinese medicine (TCM). Recent research has revealed significant advantages of TCM active ingredients in inhibiting the activation of the NLRP3 inflammasome and enhancing cardiac structure and function in HF. The study aimed to explore the impact of NLRP3 inflammasome activation on the onset and progression of HF, and to review the current advancements in utilizing TCM active ingredients to inhibit the NLRP3 inflammasome for preventing and treating HF. This provides a novel perspective for the future development of precise intervention strategies targeting the NLRP3 inflammasome to prevent and treat HF.