# The placenta as a cradle, but not source, of blood?

**Authors:** Julie Y. Chen, Kyle M. Loh

PMC · DOI: 10.1371/journal.pbio.3003021 · PLOS Biology · 2025-02-06

## TL;DR

This paper explores whether the placenta produces blood-forming stem cells or just provides a supportive environment for them.

## Contribution

The study reveals that the placenta is not a direct source of hematopoietic stem cells.

## Key findings

- The placenta does not directly generate hematopoietic stem cells.
- The placenta functions more as a supportive niche rather than a source of these cells.

## Abstract

An important question is whether the placenta is a source of, or merely a niche for, blood-forming hematopoietic stem cells. A recent PLOS Biology study suggests that the placenta does not directly give rise to hematopoietic stem cells.

An important question is whether the placenta is a source of, or merely a niche for, blood-forming hematopoietic stem cells. This Primer highlights a recent PLOS Biology study showing that the placenta does not directly give rise to hematopoietic stem cells.

## Full-text entities

- **Genes:** Slc8a1 (solute carrier family 8 (sodium/calcium exchanger), member 1) [NCBI Gene 20541] {aka D930008O12Rik, Ncx1}, Hoxa13 (homeobox A13) [NCBI Gene 15398] {aka Hd, Hox-1.10}, RUNX1 (RUNX family transcription factor 1) [NCBI Gene 861] {aka AML1, AML1-EVI-1, AMLCR1, CBF2alpha, CBFA2, EVI-1}
- **Chemicals:** carbon dioxide (MESH:D002245), oxygen (MESH:D010100)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11801694/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC11801694/full.md

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Source: https://tomesphere.com/paper/PMC11801694