# Silver Nanoparticles Improve Fluorophore Photostability: Application to a Hypericin Study

**Authors:** Grzegorz Wołąkiewicz, Monika Pietrzak, Mariusz Szabelski

PMC · DOI: 10.3390/ijms25189963 · International Journal of Molecular Sciences · 2024-09-15

## TL;DR

Silver nanoparticles can protect light-sensitive compounds like hypericin from degrading under visible light.

## Contribution

Proposes silver nanoparticles as a novel method to enhance fluorophore photostability and fluorescence intensity.

## Key findings

- Silver nanoparticles reduce photobleaching and photoreaction of hypericin.
- Fluorescence intensity of hypericin increases with silver nanoparticle addition.
- Hypericin is highly sensitive to visible light degradation.

## Abstract

Protection against the negative effects of solar radiation involves using cosmetics with a UV filter, but visible radiation can also have negative effects. We use dietary supplements and take medications; unfortunately, many of them contain substances that degrade under the influence of visible light, which transform into chemical compounds harmful to health. Manufacturers often include information on the prohibition of exposure to sunlight on the packaging, but consumers often do not read the product leaflet. The solution to this problem may be the addition of silver particles to preparations. In the presented article, we proposed the use of silver nanoparticles to reduce the photobleaching and photoreaction of fluorophore, while increasing the fluorescence intensity. For our research, we used a compound that is particularly sensitive to radiation: hypericin.

## Linked entities

- **Chemicals:** hypericin (PubChem CID 3663)

## Full-text entities

- **Chemicals:** Hypericin (MESH:C004965), Silver (MESH:D012834)

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11432501/full.md

## References

34 references — full list in the complete paper: https://tomesphere.com/paper/PMC11432501/full.md

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Source: https://tomesphere.com/paper/PMC11432501