# The VEGFA rs3025039 Variant Is a Risk Factor for Breast Cancer in Mexican Women

## TL;DR

This study finds that a specific genetic variant, rs3025039 in the VEGFA gene, is linked to a higher risk of breast cancer in Mexican women.

## Contribution

The study identifies rs3025039 as a novel risk factor for breast cancer specifically in Mexican women.

## Key findings

- The T allele of rs3025039 was significantly more frequent in breast cancer cases than in healthy controls.
- The CT genotype of rs3025039 was associated with increased breast cancer risk in Mexican women.
- The study confirms a genetic link between rs3025039 and breast cancer in this specific population.

## Abstract

Breast cancer (BC) is the leading cause of death from tumors in women worldwide, influenced by various factors, including genetics. The T allele of the single nucleotide variant (SNV) rs3025039 at position +936 of the VEGFA gene has been reported to affect the mRNA regulatory mechanisms, potentially altering VEGFA expression and increasing BC risk. This study aimed to investigate the association between rs3025039 and BC in Mexican women residing in Jalisco, Mexico. The study included 231 women with a confirmed diagnosis of BC and 201 healthy subjects as a reference group (RG). PCR–RFLP was employed for the genotyping of rs3025039, with the visualization of amplified products using polyacrylamide gel electrophoresis. Significant differences were observed in rs3025039 alleles and genotypes between BC cases and the RG (p = 0.0038). The frequency of the T allele and the CT genotype was higher in the BC group compared to the RG, with a significant difference (p = 0.0006). In conclusion, this research suggests that the SNV rs3025039 is associated with a higher risk of BC in Mexican women. These findings enhance our understanding of the genetic underpinnings of BC in this population, offering potential insights for future studies and interventions.