# The Role of ACE2 in Neurological Disorders: From Underlying Mechanisms to the Neurological Impact of COVID-19

## TL;DR

This paper reviews how ACE2, a key enzyme, influences neurological disorders and its role in the neurological effects of COVID-19.

## Contribution

The paper provides a comprehensive review of ACE2's role in the nervous system and its therapeutic potential in neurological diseases.

## Key findings

- ACE2 is involved in protecting and regulating inflammation in the nervous system.
- SARS-CoV-2's interaction with ACE2 may contribute to neurological symptoms in COVID-19.
- ACE2 offers a new therapeutic perspective for treating neurological disorders.

## Abstract

Angiotensin-converting enzyme 2 (ACE2) has become a hot topic in neuroscience research in recent years, especially in the context of the global COVID-19 pandemic, where its role in neurological diseases has received widespread attention. ACE2, as a multifunctional metalloprotease, not only plays a critical role in the cardiovascular system but also plays an important role in the protection, development, and inflammation regulation of the nervous system. The COVID-19 pandemic further highlights the importance of ACE2 in the nervous system. SARS-CoV-2 enters host cells by binding to ACE2, which may directly or indirectly affect the nervous system, leading to a range of neurological symptoms. This review aims to explore the function of ACE2 in the nervous system as well as its potential impact and therapeutic potential in various neurological diseases, providing a new perspective for the treatment of neurological disorders.