Investigating the Impact of Fasting and Refeeding on Blood Biochemical Indicators and Transcriptional Profiles in the Hypothalamus and Subcutaneous Adipose Tissue in Geese
Yi Liu, Xianze Wang, Guangquan Li, Shufang Chen, Huiyan Jia, Jiuli Dai, Daqian He
TL;DR
This study examines how fasting and refeeding affect blood chemistry and gene activity in geese, revealing metabolic and energy regulation changes.
Contribution
The study identifies specific genes and metabolic pathways in geese hypothalamus and adipose tissue affected by fasting and refeeding.
Findings
Fasting increases free fatty acids and glucagon while decreasing triglycerides, leptin, and insulin in geese blood.
Fasting downregulates fatty acid synthesis genes (LPL, SCD, ACSL1) and upregulates PLIN2 in subcutaneous adipose tissue.
Fasting alters hypothalamic gene expression, upregulating NOG, GABRD, and IGFBP-1 while downregulating POMC.
Abstract
This study explores how geese respond to fasting and subsequent refeeding by analyzing changes in blood chemistry and gene activity in the hypothalamus and subcutaneous adipose tissues. After 24 h of fasting, geese’s blood levels of key substances such as fatty acids, glucagon, triglycerides, leptin, and insulin changed noticeably. The research also identified specific genes in the hypothalamus and subcutaneous adipose tissue that are influenced by fasting, providing insight into how geese regulate energy and maintain metabolic balance in response to changes in food intake. Fasting and refeeding systems can cause significant short-term fluctuations in nutrient and energy levels, triggering adaptive physiological responses in animals. This study examines the effects of fasting and refeeding on blood biochemical indicators and transcriptional profiles in the hypothalamus and subcutaneous…
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Taxonomy
TopicsRegulation of Appetite and Obesity · Adipose Tissue and Metabolism · Apelin-related biomedical research