miRNA in the Diagnosis and Treatment of Critical Limb Ischemia

TL;DR

This study explores the role of specific miRNAs in chronic limb-threatening ischemia and their potential for future treatments.

Contribution

The study investigates the expression of miR-199a, miR-20a, and miR-30c in patients with critical limb ischemia before and after revascularization.

Findings

The study aims to determine if these miRNAs are involved in critical ischemia.

It explores the potential of these miRNAs for future therapeutic applications.

Expression levels of the miRNAs will be compared in pre- and post-revascularization periods.

Abstract

Chronic threatening limb ischemia of the inferior limbs (CLTI) is the final stage of peripheral arterial disease (PAD) and is one of the most feared atherosclerotic manifestations because if left untreated, in time, it can lead to amputation. Although there are currently numerous treatment techniques, both open and endovascular, it is a pathology that has no underlying treatment. Therefore, current studies are very much focused on new therapeutic possibilities that can be applied in the early stages of the atherosclerotic process. In numerous studies in the literature, miRNAs have been identified as important markers of atherosclerosis. The present study aims to identify the expression of three miRNAs—miR-199a, miR-20a, and miR-30c—in patients with chronic limb-threatening ischemia in the pre- and post-revascularization periods. The aim of the study is to identify whether these three markers play a role in critical ischemia and whether they have the potential for future use in new treatments of this pathology.

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