# Additional Cover

## TL;DR

This paper explores how transcranial direct current stimulation improves the brain's protection against injury during isoflurane preconditioning.

## Contribution

It identifies a new mechanism involving the nuclear protein Akirin2 in this protective process.

## Key findings

- Transcranial direct current stimulation enhances isoflurane preconditioning effects.
- The nuclear protein Akirin2 is associated with this protective mechanism.
- This suggests a novel therapeutic approach for cerebral ischemia/reperfusion injury.

## Abstract

The cover image is based on the article Transcranial direct current stimulation enhances the protective effect of isoflurane preconditioning on cerebral ischemia/reperfusion injury: A new mechanism associated with the nuclear protein Akirin2 by Xiangyi Kong et al., https://doi.org/10.1111/cns.70033.