# Docetaxel-Induced Pneumonitis in a Patient With Metastatic Lung Adenocarcinoma

**Authors:** Brian Chua, Yi Hern Tan

PMC · DOI: 10.7759/cureus.67939 · 2024-08-27

## TL;DR

A patient with lung cancer developed pneumonitis after docetaxel treatment and improved with steroids.

## Contribution

This case highlights docetaxel-induced pneumonitis as a rare but important side effect in lung cancer treatment.

## Key findings

- The patient showed a favorable response to docetaxel but developed pneumonitis.
- High-dose steroids were effective in treating the pneumonitis after infections were ruled out.

## Abstract

Docetaxel is a taxane anti-neoplastic agent commonly used in the treatment of solid-organ tumours. Here, we describe a case of a patient with metastatic lung adenocarcinoma who had disease progression following initial treatment with a combination of pembrolizumab, pemetrexed and carboplatin. She received three cycles of docetaxel and had a favourable oncological response but was admitted for breathlessness following the third cycle. A repeat computed tomography scan of the thorax showed predominantly right-sided ground-glass opacities and consolidation. The patient underwent high-risk bronchoscopy and bronchoalveolar lavage. Once infection was confidently ruled out, she was started on high-dose steroid therapy and responded to treatment.

## Linked entities

- **Chemicals:** docetaxel (PubChem CID 148124), pemetrexed (PubChem CID 135410875), carboplatin (PubChem CID 426756)
- **Diseases:** pneumonitis (MONDO:0043905)

## Full-text entities

- **Diseases:** Pneumonitis (MESH:D011014), solid-organ tumours (MESH:D009369), Metastatic Lung Adenocarcinoma (MESH:D000077192), breathlessness (MESH:D004417), infection (MESH:D007239)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11426334/full.md

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Source: https://tomesphere.com/paper/PMC11426334