# Intermittent hypoxic training – derived exosomes in stroke rehabilitation

## TL;DR

This mini-review explores using exosomes from intermittent hypoxic training to treat ischemic stroke, which could help overcome the blood-brain barrier challenge.

## Contribution

The novelty lies in proposing exosomes from intermittent hypoxic conditioning as a potential stroke rehabilitation strategy.

## Key findings

- Exosomes can cross the blood-brain barrier, making them promising for stroke treatment.
- Intermittent hypoxic training may generate exosomes with therapeutic potential for ischemic stroke.
- Current stroke treatments are limited, and this approach could offer a new intervention pathway.

## Abstract

Ischemic stroke is the fourth leading cause of adult disability in the US, and it is a huge social burden all over the world. However, the efficient treatment of ischemic stroke is not available. An apparent reason for failing to find or develop an intervention for ischemic stroke is contributed to the tight blood–brain barrier (BBB). The unique characteristics of exosomes that can traverse BBB have been highlighted among researchers investigating interventions for ischemic stroke conditions. Additionally, intermittent hypoxic training has been considered a potential intervention in the treatment or rehabilitation process of ischemic stroke patients. In this mini-review, we are going to review the possibility of applying exosomes produced by a subject who does intermittent hypoxic conditioning in a treatment program for ischemic stroke.