# Anti-GBM Nephritis in an 11-Year-Old Female Child: A Rare Case Report

**Authors:** Shivani Kale, Manojkumar Patil, Shailaja Mane, Neha Thorbole, Manoj Matnani

PMC · DOI: 10.7759/cureus.67736 · Cureus · 2024-08-25

## TL;DR

This paper reports a rare case of anti-GBM nephritis in an 11-year-old girl, highlighting the importance of early diagnosis and treatment.

## Contribution

The novelty lies in presenting a rare pediatric case of anti-GBM nephritis with clinical and diagnostic insights.

## Key findings

- An 11-year-old female presented with symptoms progressing to hypertension and requiring hemodialysis.
- Renal biopsy confirmed anti-GBM nephritis with IgG linear deposits.
- Treatment included intravenous methylprednisolone and antihypertensives with ongoing dialysis.

## Abstract

Anti-glomerular basement membrane (GBM) nephritis is a rare autoimmune condition involving the glomerular basement membrane of the kidneys. This case report describes an 11-year-old female who presented with edema, decreased urine output, and altered sensorium, progressing to hypertension and requiring emergent hemodialysis. A renal biopsy showing Immunoglobulin G (IgG) linear deposits confirmed the diagnosis. The patient was treated with intravenous methylprednisolone and antihypertensives and then scheduled for regular dialysis. This case underscores the critical need for early diagnosis and aggressive management to prevent severe complications in pediatric anti-GBM disease.

## Linked entities

- **Chemicals:** methylprednisolone (PubChem CID 6741)

## Full-text entities

- **Diseases:** hypertension (MESH:D006973), autoimmune condition (MESH:D001327), Anti-GBM Nephritis (MESH:D019867), edema (MESH:D004487), decreased urine output (MESH:D002303)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11421877/full.md

## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC11421877/full.md

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Source: https://tomesphere.com/paper/PMC11421877