# The primary systemic vasculitis associated optic neuritis: a retrospective analysis in a single center over 10 years

## TL;DR

This study examines optic neuritis caused by primary systemic vasculitis, analyzing clinical features and outcomes over 10 years.

## Contribution

The study provides a detailed retrospective analysis of optic neuritis cases linked to various systemic vasculitis types.

## Key findings

- 14 patients with vasculitis-associated optic neuritis showed optic nerve enlargement or enhancement on MRI.
- Disease onset occurred in fall or winter, with poor visual outcomes despite treatment.
- Potential pathogenesis includes autoantibody attack, ischemia, or blood-brain barrier disruption.

## Abstract

To investigate the clinical and image characteristics of primary systemic vasculitis-associated optic neuritis patients.

This is a retrospective study. The patients clinically diagnosed with primary system vasculitis-induced optic neuritis were recruited from March 2013 to December 2023. All cases received orbital magnetic resonance imaging scans were analyzed. The ocular findings, systemic manifestations, laboratory data and prognosis were reviewed retrospectively. In addition, the related literature was reviewed.

Fourteen patients (21 eyes), including 10 men and 4 women, were enrolled in this study. The ages ranged from 30 to 86 years in this cohort. Orbits MRI detects the enlargement and/or enhancement of the optic nerve. Cases 1–5 reported a confirmed diagnosis of Takayasu’s arteritis, and cases 6–8 had giant cell arteritis. Cases 9–13 were antineutrophil cytoplasmic antibody-associated vasculitis. Case 14 was Cogan’s syndrome. Mult organs and tissues, such as the kidneys, heart, paranasal sinuses, meninges, and respiratory system, were involved. In all of the 14 involved patients, the disease onset was either during the fall or winter season. There were no or only slight improvements in visual activity after conventional therapies.

The autoantibodies’ attack on the optic nerve, ischemic damage, or destruction of the blood–brain barrier may be the potential pathogenesis of vasculitis-associated optic neuritis. Even with prompt and aggressive clinical interventions, the prognosis remains unsatisfactory.