# Current interventional model for movement in Parkinson’s disease: network meta-analysis based on the improvement of motor ability

## TL;DR

This study identifies archery, cycling, and binary rhythm dance as top exercises for improving motor function in Parkinson’s disease patients.

## Contribution

A network meta-analysis ranks specific exercise interventions for motor improvement in Parkinson’s disease.

## Key findings

- Archery had the highest ranking probability (95.6%) for motor function improvement.
- Cycling and binary rhythm dance also showed high effectiveness (80.9% and 80.8%, respectively).
- 71 studies with 3,732 participants were analyzed to compare 27 distinct exercise interventions.

## Abstract

To identify optimally therapeutic exercise interventions for improving motor ability among patients with Parkinson’s disease (PD), we conducted a network meta-analysis (NMA) of randomized controlled trials comparing different exercise regimens.

Relevant RCTs were retrieved by searching PubMed, Embase, Cochrane, Web of Science, CINAHL, CBM, China National Knowledge Infrastructure (CNKI), Wan fang, VIP, and other databases from inception to July 9, 2023 is available in English as the primary language. Exercise outcomes as measured by Movement Disorder Society- Unified Parkinson’s Disease Rating Scale Part III (MDS-UPDRS-III) score change were evaluated and ranked using STATA software version 18.0. All included studies were assessed for methodological quality using the Cochrane Risk of Bias tool.

The final NMA included 71 studies involving 3,732 participants, 87 intervention experiments, and 27distinct interventions. Although most exercise interventions showed some efficacy (reducing MDS-UPDRS-III score), cumulative ranking probability surface (SUCRA) values indicated that the best exercise interventions for motor function improvement were archery (95.6%), riding a bicycle (80.9%), and binary rhythm dance (80.8%).

An exercise intervention comprising archery, cycling, and(or) binary rhythm dance may yield superior improvements in motor function among patients with Parkinson’s disease.