# Giant Basal Cell Carcinoma Within a Marjolin's Ulcer: A Case Discussion

**Authors:** Steven Latta, Silas J Helbig, Karine Kasti, Elizabeth Paulus

PMC · DOI: 10.7759/cureus.67629 · Cureus · 2024-08-23

## TL;DR

A rare case of giant basal cell carcinoma within a Marjolin's ulcer is reported, along with other skin cancers in a 76-year-old man with multiple health issues.

## Contribution

This case highlights the unusual occurrence of a giant basal cell carcinoma within a Marjolin's ulcer, expanding the known spectrum of these aggressive tumors.

## Key findings

- A 76-year-old male presented with a large basal cell carcinoma within a non-healing wound.
- The patient also had a verruciform squamous cell carcinoma adjacent to a Marjolin's ulcer.
- Treatment involved surgical excision followed by radiation therapy due to poor surgical margins.

## Abstract

Marjolin's ulcers are cutaneous malignancies that arise from chronic wounds, often secondary to burns. While squamous cell carcinoma is the most prevalent type, rare instances of other tumors, such as basal cell carcinoma, have occurred. These tumors are challenging to treat due to their high recurrence rate and aggressive behavior. In this report, we present the case of a 76-year-old male with a history significant for polysubstance use, human immunodeficiency virus (HIV), hepatitis C, and Agent Orange exposure who presented with a large fungating basal cell carcinoma secondary to a non-healing wound. Additionally, several other cutaneous malignancies were present, including a large verruciform squamous cell carcinoma adjacent to a Marjolin's ulcer. These lesions were managed with surgical excision, followed by radiation therapy due to suboptimal margins.

## Linked entities

- **Diseases:** basal cell carcinoma (MONDO:0005341), squamous cell carcinoma (MONDO:0005096)

## Full-text entities

- **Diseases:** Marjolin's Ulcer (MESH:D014456), Giant Basal Cell Carcinoma (MESH:D018286), cutaneous malignancies (MESH:C562393), hepatitis C (MESH:D019698), basal cell carcinoma (MESH:D002280), squamous cell carcinoma (MESH:D002294), tumors (MESH:D009369), burns (MESH:D002056)
- **Chemicals:** polysubstance (-), Agent Orange (MESH:D000075182)
- **Species:** Human immunodeficiency virus (species) [taxon 12721]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11419596/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC11419596/full.md

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Source: https://tomesphere.com/paper/PMC11419596