# Pseudomyxoma Peritonei Arising From a Mucinous Ovarian Borderline Tumor Treated With Paclitaxel, Cisplatin, and Bevacizumab: A Case Report

**Authors:** Kentaro Niwa, Kenji Niwa, Masanori Isobe, Rui Kyogoku, Takuji Tanaka

PMC · DOI: 10.7759/cureus.67554 · Cureus · 2024-08-23

## TL;DR

A rare case of pseudomyxoma peritonei from an ovarian tumor was successfully treated with chemotherapy and bevacizumab.

## Contribution

This case report highlights the successful treatment of PMP with a KRAS mutation using bevacizumab-containing chemotherapy.

## Key findings

- PMP arose from an ovarian mucinous borderline tumor with a KRAS mutation.
- Treatment with bevacizumab-containing chemotherapy led to complete remission.
- Laparoscopic surgery followed by appendectomy was part of the treatment approach.

## Abstract

Pseudomyxoma peritonei (PMP) is a rare disease caused by primary mucinous neoplasms. Here, we describe a case where a large ovarian tumor was initially removed laparoscopically, followed by an appendectomy. The patient was diagnosed with PMP arising from an ovarian mucinous borderline tumor with a KRAS mutation. Treatment included bevacizumab-containing chemotherapy, resulting in complete remission.

## Linked entities

- **Genes:** KRAS (KRAS proto-oncogene, GTPase) [NCBI Gene 3845]
- **Chemicals:** paclitaxel (PubChem CID 36314), cisplatin (PubChem CID 5460033)
- **Diseases:** pseudomyxoma peritonei (MONDO:0017048)

## Full-text entities

- **Genes:** KRAS (KRAS proto-oncogene, GTPase) [NCBI Gene 3845] {aka 'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A}
- **Diseases:** mucinous neoplasms (MESH:D018297), Mucinous Ovarian Borderline Tumor (MESH:D010051), PMP (MESH:D011553)
- **Chemicals:** Bevacizumab (MESH:D000068258), Paclitaxel (MESH:D017239), Cisplatin (MESH:D002945)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11416708/full.md

## References

17 references — full list in the complete paper: https://tomesphere.com/paper/PMC11416708/full.md

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Source: https://tomesphere.com/paper/PMC11416708