# From Psychosis to Recovery: A Case Report of N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis

**Authors:** Sava Nanda Gopal, Deepthi Vakati, Saranya Palanisamy, Kanimozhi David, Kannan Rajendran

PMC · DOI: 10.7759/cureus.67272 · 2024-08-20

## TL;DR

This case report describes a patient's journey from psychosis to recovery due to NMDA receptor encephalitis, a rare autoimmune brain condition.

## Contribution

The novelty lies in the detailed documentation of clinical progression and treatment of NMDA receptor encephalitis in a young individual.

## Key findings

- The patient's symptoms began with psychosis and memory issues, progressing to seizures and autonomic instability.
- Diagnosis and treatment led to recovery, illustrating the disease's typical clinical course.
- The case emphasizes the importance of recognizing autoimmune causes in neuropsychiatric presentations.

## Abstract

Autoimmune N-methyl-D-aspartate (NMDA) receptor encephalitis is an increasingly recognized cause of severe neuropsychiatric illness, particularly in young individuals. This case report presents a detailed account of a patient diagnosed with NMDA receptor encephalitis, highlighting the clinical presentation, diagnostic challenges, and treatment approach. The patient exhibited initial symptoms of psychosis and memory disturbances, which rapidly progressed to seizures and autonomic instability, reflecting the characteristic progression of the disorder.

## Linked entities

- **Chemicals:** N-Methyl-D-Aspartate (PubChem CID 22880)
- **Diseases:** psychosis (MONDO:0005485)

## Full-text entities

- **Diseases:** Psychosis (MESH:D011618), memory disturbances (MESH:D008569), autonomic instability (MESH:D043171), Autoimmune N-methyl-D-aspartate (NMDA) receptor encephalitis (MESH:D060426), seizures (MESH:D012640), neuropsychiatric illness (MESH:C000631768)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11411395/full.md

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Source: https://tomesphere.com/paper/PMC11411395