Pregabalin-Induced Bullous Pemphigoid: A Case Report of a Rare Drug-Triggered Autoimmune Skin Disorder

TL;DR

A 75-year-old woman developed a rare skin condition called bullous pemphigoid after taking pregabalin, highlighting the drug's potential to trigger autoimmune skin disorders.

Contribution

This case report identifies pregabalin as a possible trigger for bullous pemphigoid, a rare autoimmune skin disorder.

Findings

A 75-year-old female developed bullous pemphigoid after starting pregabalin.

Symptoms improved after discontinuing pregabalin and using topical corticosteroids.

The case suggests a link between pregabalin and autoimmune blistering skin disorders.

Abstract

Bullous pemphigoid (BP) is a common autoimmune blistering disorder primarily affecting the elderly, characterized by intense pruritus and tense bullae on the skin. We report the case of a 75-year-old female with a history of breast cancer who developed BP on both feet following the initiation of pregabalin for pain management. Histopathological examination confirmed BP, and symptoms improved with topical corticosteroid treatment and discontinuation of pregabalin. This case highlights the potential of pregabalin to induce BP and underscores the importance of recognizing medication-induced bullous diseases for prompt diagnosis and management.

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