# Isolated external jugular thrombophlebitis secondary to acute pharyngitis: a case report and a review of the literature

**Authors:** Uche C. Ezeh, Naomi Tesema, Sukaina Hasnie, Philip J. Kahn, Max M. April

PMC · DOI: 10.1186/s13052-024-01760-4 · Italian Journal of Pediatrics · 2024-09-16

## TL;DR

A 13-year-old with severe throat infection developed rare external jugular vein blood clot on the opposite side of facial swelling.

## Contribution

First reported case of external jugular thrombophlebitis with sinusitis on the contralateral side in a pediatric patient.

## Key findings

- EJT occurred in a 13-year-old with acute pharyngitis and left-sided sinusitis.
- Anticoagulation and antibiotics led to resolution of thrombosis and sinus disease.
- No prior reports of contralateral EJT and sinusitis in pediatric populations exist.

## Abstract

External Jugular Thrombophlebitis (EJT) is a rare clinical phenomenon with few reports in the literature, especially in the pediatric population. This is a report of an unusual case of right-sided EJT in a pediatric patient secondary to acute pharyngitis with sinusitis most prominent on the left side.

A 13-year-old presented to the emergency department with worsening upper respiratory infectious (URI) symptoms and facial swelling, cough, throat pain, and emesis. The patient had traveled to Switzerland and received amoxicillin for strep throat 6 weeks before this hospitalization. Physical examination revealed nasal purulence, allodynia over the right side of the face without overlying erythema, and oropharyngeal exudate. CT scan revealed left-sided predominate sinusitis and right external jugular vein thrombosis. Blood cultures confirmed the presence of group A streptococcus infection. Treatment included IV antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), IV steroids, and anticoagulation. Follow-up imaging demonstrated improvement in thrombosis, cellulitis, and sinus disease. The patient was discharged on antibiotics for 6 weeks and anticoagulation for 10 weeks. Follow-up imaging at 6 months revealed no EJT, and medications were discontinued.

EJT is a rare condition, and to our knowledge, no reports of EJT with sinusitis most pronounced on the contralateral side have been published. Physicians will benefit from noting clinical signs of EJT such as facial edema, headache, erythema, and palpable neck mass, especially if these symptoms occur with URI symptoms refractory to treatment. The use of anticoagulation is controversial for internal jugular vein thrombosis, and while no guidelines for EJT exist, anticoagulation is likely not necessary save for severe complications.

## Linked entities

- **Chemicals:** amoxicillin (PubChem CID 33613), steroids (PubChem CID 139082353)
- **Diseases:** acute pharyngitis (MONDO:0002258), sinusitis (MONDO:0005961)

## Full-text entities

- **Diseases:** throat pain (MESH:D010146), thrombosis (MESH:D013927), EJT (MESH:D013924), allodynia (MESH:D006930), PRESENTATION (MESH:D001946), headache (MESH:D006261), neck mass (MESH:D006258), cough (MESH:D003371), group A streptococcus infection (MESH:D011008), pharyngitis (MESH:D010612), nasal purulence (MESH:D009668), erythema (MESH:D004890), emesis (MESH:D014839), facial edema (MESH:D004487), strep throat (MESH:D013290), external jugular vein thrombosis (MESH:D012170), upper respiratory infectious (URI) symptoms (MESH:D012818), cellulitis (MESH:D002481), sinus disease (MESH:D012852)
- **Chemicals:** amoxicillin (MESH:D000658), steroids (MESH:D013256)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

4 references — full list in the complete paper: https://tomesphere.com/paper/PMC11406880/full.md

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Source: https://tomesphere.com/paper/PMC11406880