# Multivariate mapping of brain pathology: a step forward with stumbling blocks

## TL;DR

This paper discusses the progress and challenges in using multivariate methods to map brain pathology.

## Contribution

It highlights the validation of multivariate lesion inference approaches against ground-truth data.

## Key findings

- Multivariate methods offer improved accuracy in lesion inference.
- Ground-truth validation reveals persistent challenges in these approaches.
- Uni- and multivariate methods have distinct strengths and limitations.

## Abstract

This scientific commentary refers to ‘Ground-truth validation of uni- and multivariate lesion inference approaches’, by Zavaglia et al. (https://doi.org/10.1093/braincomms/fcae251).