Broad range molecular detection methods identify only Borrelia spp. in erythema migrans biopsies and blood of tick-bitten patients
Philippe Pérot, Laura Tondeur, Sara Moutailler, Delphine Chrétien, Nicole Corre-Catelin, Muriel Vayssier-Taussat, Marc Eloit, Catherine Chirouze, Céline Cazorla, Laurence Arowas, Laurence Arowas, Elisabeth Botelho-Nevers, Céline Cazorla, Catherine Chirouze, Delphine Chrétien
TL;DR
This study found that only Borrelia bacteria, not other pathogens, were present in skin and blood samples from patients with tick-bite-related rashes.
Contribution
The study confirms Borrelia spp. as the sole pathogen in erythema migrans, using advanced detection methods.
Findings
No microorganisms other than Borrelia spp. were detected in skin biopsies.
Blood samples also showed no evidence of other pathogens.
High-throughput and metagenomic methods confirmed the specificity of Borrelia spp. presence.
Abstract
In this multicenter study conducted in France, we challenged the hypothesis of the transmission of pathogens other than Borrelia spp. in 22 patients developing erythema migrans following a tick bite. Using a combination of high-throughput microfluidic PCRs and agnostic metagenomics on skin biopsies and blood samples, no microorganisms other than Borrelia spp. was found.
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Taxonomy
TopicsVector-borne infectious diseases · Viral Infections and Vectors · Vector-Borne Animal Diseases