Experiments and Calculation on New N,N-bis-Tetrahydroacridines
Madalina-Marina Hrubaru, Constantin Draghici, Francis Aurelien Ngounoue Kamga, Elena Diacu, ThankGod C. Egemonye, Anthony C. Ekennia, Eleonora-Mihaela Ungureanu
TL;DR
This paper reports the synthesis and study of new N,N-bis-tetrahydroacridines, showing potential for use in medicine and corrosion protection.
Contribution
The novel synthesis of N,N-bis-tetrahydroacridines and their comprehensive experimental and computational characterization.
Findings
The compounds were successfully synthesized and confirmed using NMR, MS, and FT-IR.
DFT calculations revealed their electronic properties and lowest energy conformers.
UV–Vis and voltammetric studies showed potential for pharmaceutical and corrosion inhibition applications.
Abstract
Tetrahydroacridines arouse particular interest due to the potential possibilities of application in the medical field and protection against corrosion. Bis-tetrahydroacridines were newly synthesized by Pfitzinger condensation of 5,5′-(ethane-1,2-diyl) diindoline-2,3-dione with several cyclanones. NMR, MS, and FT-IR were used to prove their molecular structure. In addition, a computer-aided study was performed for the lowest energy conformers of each structure, in vacuum conditions, at ground state using DFT models to assess their electronic properties. UV–Vis and voltammetric methods (cyclic voltammetry, differential pulse voltammetry, and rotating disk electrode voltammetry) were used to investigate their optical and electrochemical properties. The results obtained for these π-conjugated heteroaromatic compounds lead to the conclusion that they have real potential in applications in…
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Taxonomy
TopicsSynthesis and Biological Evaluation · Chemical Reaction Mechanisms · Cancer therapeutics and mechanisms