Development of Thyme-Infused Polydimethylsiloxane Composites for Enhanced Antibacterial Wound Dressings
Sara Sarraj, Małgorzata Szymiczek, Anna Mertas, Agata Soluch, Dariusz Jędrejek, Sebastian Jurczyk
TL;DR
This paper explores adding thyme to a flexible polymer to create better wound dressings with improved antibacterial and mechanical properties.
Contribution
The novel use of thyme in polydimethylsiloxane composites for wound dressings is introduced, enhancing antibacterial and mechanical performance.
Findings
Thyme incorporation improved mechanical properties and antibacterial activity of PDMS composites.
Cell viability exceeded 70%, with optimal results at 2.5 wt.% thyme.
Hardness decreased with higher thyme content due to terpene-induced polymerization inhibition.
Abstract
Polydimethylsiloxane (PDMS) is widely used in biomedical applications due to its biocompatibility and flexibility but faces challenges due to its hydrophobicity and limited mechanical strength. This study explores the incorporation of thyme (Thymus vulgaris L.) into PDMS to enhance its properties for wound dressing applications. PDMS composites containing 2.5 wt.% and 5 wt.% of thyme were prepared and evaluated for physical, chemical, mechanical, and biological properties. Scanning electron microscopy, contact angle measurements, absorption tests, Fourier-transform infrared spectroscopy, differential scanning calorimetry, hardness, tensile testing, antibacterial activity, and cell viability assays were conducted. Thyme integration improved mechanical properties with increased absorption and preserved hydrophobicity. FTIR and DSC analyses indicated minimally altered crystallinity and…
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Taxonomy
TopicsWound Healing and Treatments · Antimicrobial agents and applications · Silk-based biomaterials and applications