# Myxoid Liposarcomas of the Thigh: Pre-Operative Presentation, Clinical Outcomes, and Functional Results of Surgical Treatment

## TL;DR

This study examines the treatment and outcomes of thigh myxoid liposarcomas, focusing on surgical resection and functional recovery.

## Contribution

The study provides insights into the impact of resection margins on recurrence rates and functional outcomes in thigh myxoid liposarcomas.

## Key findings

- Wide resection margins were achieved in 80% of cases, associated with lower local recurrence rates.
- High-grade tumors had a 10% metastasis rate, while marginal resections correlated with higher local recurrence.
- Functional outcomes improved post-surgery, with MSTS scores increasing from 22.9 to 27.3.

## Abstract

Myxoid liposarcomas are malignant soft-tissue sarcomas whose treatment represents a challenge, even for the most experienced surgeon. In this study, we report on our experience with the treatment of myxoid liposarcomas of the thigh. Our retrospective analysis included myxoid liposarcomas of the thigh treated with surgical resection between 2016 and 2022. Resection margins, complications, local recurrences, and metastases were recorded. The oncological outcome of each case was evaluated at their latest follow-up. Adjuvant therapies were administered according to the ESMO guidelines. Functionality was assessed with the MSTS score before surgery and at the patients’ latest follow-up. Thirty cases (ten high-grade and 20 low-grade) were included. The mean diameter was 11.8 cm. Twenty-four cases had wide margins (80%) and six (20%) were marginal. Five cases (60% marginal) had local recurrences (17%). Marginal resection was associated with a higher risk of local recurrence (p = 0.041). Three cases with high-grade tumors (10%) developed metastases. At the patients’ latest follow-up, their mean MSTS score had risen from 22.9 to 27.3. While tumor grade influences the risk of metastases, the quality of resection margins can determine the local recurrence rate. An adequate surgery can lead to good post-operative functional outcomes.