# Silver hair in a neonate: a tale of 2 fatal cases

## TL;DR

This paper discusses two rare cases of neonates with silver hair, exploring their connection to genetic disorders and the importance of diagnosis.

## Contribution

The paper presents two unique clinical cases of silver hair syndrome in preterm neonates and emphasizes the diagnostic value of hair mount and genetic testing.

## Key findings

- Silver hair in neonates can be a sign of underlying immunodeficiency disorders like Griscelli syndrome.
- Hair mount and genetic testing are crucial for diagnosing and differentiating between related conditions.
- Preterm neonates with silver hair may not show other complications but require thorough evaluation for systemic abnormalities.

## Abstract

Silver hair in a neonate is an uncommon occurrence. The aetiology of this condition is varied and is associated with immunodeficiency disorders such as Griscelli syndrome and Chédiak-Higashi syndrome. A preterm neonate with Griscelli syndrome type 2 might present with just silver colour staining of hair including the lanugo hair with no other complications. In those with associated systemic abnormalities such as congenital pulmonary airway malformation, further evaluation for conditions such as Menke-Kinke hair syndrome is required. In this case series, we describe two unique cases of silver hair syndrome in preterm neonates with their clinical description, course in the hospital, role of hair mount and genetic testing for further identification and diagnosis of this disorder.