# Role of Laparoscopy in Severe Gastrointestinal Bleeding Secondary to Coats Plus Syndrome

## TL;DR

This paper presents a case where laparoscopic techniques successfully diagnosed and treated severe GI bleeding in a rare genetic disorder called Coats plus syndrome.

## Contribution

The paper introduces laparoscopic assisted enteroscopy with enterectomy as a novel approach for managing GI bleeding in Coats plus syndrome.

## Key findings

- Conventional endoscopy failed to identify the source of GI bleeding in a 20-year-old female with Coats plus syndrome.
- Laparoscopic assisted enteroscopy with enterectomy successfully diagnosed and treated the bleeding.
- This approach offers a potential new diagnostic and therapeutic modality for similar cases.

## Abstract

Coats plus syndrome (CPS) is an exceedingly rare genetic disorder associated with premature telomere shortening. The syndrome, also known as cerebroretinal microangiopathy with calcifications and cysts, has a multisystemic manifestation. It may present as brain abnormalities, seizures, osteopenia, prenatal and postnatal growth deficiency, and portal hypertension, among others. Up to 40% of affected individuals manifest recurrent gastrointestinal (GI) bleeding which can be life-threatening in some cases. Treatment for GI bleeding is not standardized and is therefore individualized based on the patient's clinical status, comorbidities, and resource availability. We herein present a case of a 20-year-old female with CPS and a two-year history of severe recurrent GI bleeding unable to be identified by conventional endoscopy. This report highlights successful laparoscopic assisted enteroscopy with enterectomy as a novel diagnostic and therapeutic modality in this population.