Interleukin‐12 sustained release system promotes hematopoietic recovery after radiation injury
Chuanchuan Lin, Yang Xiang, Yangyang Zhang, Zhenxing Yang, Nanxi Chen, Weiwei Zhang, Lanyue Hu, Jianxin Chen, Ya Luo, Xueying Wang, Yanni Xiao, Qing Zhang, Xi Ran, Li Chen, Jigang Dai, Zhongjun Li, Qian Ran
TL;DR
A new injectable hydrogel slowly releases interleukin-12 to help repair blood cell production after radiation injury.
Contribution
A novel hydrogel system for sustained IL-12 delivery that promotes hematopoietic recovery after radiation.
Findings
Local administration of RGD-Alg/Laponite@IL-12 increased survival and hematopoietic recovery in irradiated mice.
The hydrogel activated the IL-12R-PI3K/AKT signaling axis, enhancing mesenchymal stem cell function and microenvironment repair.
This strategy offers a new therapeutic approach for radiation-induced hematopoietic injury.
Abstract
The continuous production of mature blood cell lineages is maintained by hematopoietic stem cells but they are highly susceptible to damage by ionizing radiation (IR) that induces death. Thus, devising therapeutic strategies that can mitigate hematopoietic toxicity caused by IR would benefit acute radiation syndrome (ARS) victims and patients receiving radiotherapy. Herein, we describe the preparation of an injectable hydrogel formulation based on Arg‐Gly‐Asp‐alginate (RGD‐Alg) and Laponite using a simple mixing method that ensured a slow and sustained release of interleukin‐12 (IL‐12) (RGD‐Alg/Laponite@IL‐12). The local administration of RGD‐Alg/Laponite@IL‐12 increased survival rates and promoted the hematopoietic recovery of mice who had received sublethal‐dose irradiation. Local intra‐bone marrow (intra‐BM) injection of RGD‐Alg/Laponite@IL‐12 hydrogel effectively stimulated IL12…
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Taxonomy
TopicsEffects of Radiation Exposure · Hematopoietic Stem Cell Transplantation · Neuroblastoma Research and Treatments