# An Infrequent Histopathological Diagnosis in a Prevalent Systemic Disease: A Case of Renal Sarcoidosis

**Authors:** Sónia Reis Santos, Ana Cunha Rodrigues, José Luís Melo Pereira, Marta Costa, Nelson Domingues

PMC · DOI: 10.7759/cureus.66633 · Cureus · 2024-08-11

## TL;DR

A 59-year-old woman with sarcoidosis developed kidney issues, which improved after corticosteroid treatment.

## Contribution

This case highlights the rare occurrence of renal sarcoidosis and its successful treatment with corticosteroids.

## Key findings

- Renal dysfunction was initially attributed to acute interstitial nephritis and hypercalcemia.
- Corticosteroid therapy led to recovery of renal function and normalization of serum calcium levels.

## Abstract

Sarcoidosis is a multisystemic granulomatous disease that results from an aberrant immunological response to certain antigens. Although pulmonary involvement predominates, renal involvement may also occur. We present the case of a 59-year-old woman with a recent diagnosis of hepatic sarcoidosis and a history of non-compliance with treatment who was admitted to the hospital for study of acute kidney injury. Renal dysfunction was assumed to be a result of acute interstitial nephritis, as revealed on renal biopsy, and alterations in glomerular hemodynamics due to hypercalcemia. Renal function recovered and serum calcium levels normalized with the introduction of corticosteroid therapy.

## Linked entities

- **Diseases:** sarcoidosis (MONDO:0008399), acute kidney injury (MONDO:0002492), hypercalcemia (MONDO:0001566)

## Full-text entities

- **Diseases:** acute kidney injury (MESH:D058186), renal involvement (MESH:C565423), multisystemic granulomatous disease (MESH:D006105), Renal dysfunction (MESH:D007674), hypercalcemia (MESH:D006934), pulmonary involvement (MESH:C566343), Renal Sarcoidosis (MESH:D012507), interstitial nephritis (MESH:D009395)
- **Chemicals:** calcium (MESH:D002118)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC11386368/full.md

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Source: https://tomesphere.com/paper/PMC11386368