# Whole-genome sequencing of Helicobacter pylori isolates from Native American gastric biopsy specimens

**Authors:** Kimberly Celona, Charles H. D. Williamson, Rishi Dholakia, Jason W. Sahl, Fernando P. Monroy, Erik W. Settles

PMC · DOI: 10.1128/mra.00160-24 · Microbiology Resource Announcements · 2024-08-14

## TL;DR

This study uses whole-genome sequencing to analyze Helicobacter pylori isolates from Native American patients with gastric disease.

## Contribution

The study provides new genomic data on H. pylori isolates from a specific indigenous population in the U.S.

## Key findings

- Three H. pylori isolates from Native American patients were sequenced.
- The isolates originated from individuals with gastric disease.
- The data may help understand H. pylori's role in gastric cancer in indigenous populations.

## Abstract

Helicobacter pylori infection has been linked to gastrointestinal diseases including gastric cancer. High rates of H. pylori infection and gastric cancer have been reported in indigenous populations within the United States. We report whole-genome sequencing of three H. pylori isolates originating from Native American patients presenting with gastric disease.

## Linked entities

- **Diseases:** gastric cancer (MONDO:0001056)
- **Species:** Helicobacter pylori (taxon 210)

## Full-text entities

- **Diseases:** gastric disease (MESH:D013272), gastrointestinal diseases (MESH:D005767), H. pylori infection (MESH:D016481), gastric cancer (MESH:D013274)
- **Species:** Homo sapiens (human, species) [taxon 9606], Helicobacter pylori (species) [taxon 210]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11385945/full.md

## References

26 references — full list in the complete paper: https://tomesphere.com/paper/PMC11385945/full.md

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Source: https://tomesphere.com/paper/PMC11385945