Successful Treatment of Risperidone-Induced Hypothermia With Aripiprazole: A Brief Case Report and a Literature Review

TL;DR

A 68-year-old man with hypothermia caused by risperidone was successfully treated with aripiprazole, highlighting the importance of monitoring temperature in antipsychotic users.

Contribution

This case report demonstrates aripiprazole as an effective alternative for managing antipsychotic-induced hypothermia.

Findings

Switching from risperidone to aripiprazole normalized the patient's temperature.

Regular temperature monitoring is essential for early detection of antipsychotic-induced hypothermia.

Abstract

Hypothermia, a potentially fatal condition, can result from various internal causes, including certain medications. Antipsychotics, in particular, are associated with hypothermia, typically emerging 7-10 days after dosage adjustments. Here, we report the case of a 68-year-old male with a history of cerebral palsy, bipolar disorder, and paranoid schizophrenia who was admitted due to poor oral intake and was found to have persistent hypothermia despite active external rewarming. After substituting risperidone with aripiprazole, his temperature normalized, and he experienced no further hypothermic episodes.

Antipsychotic-induced hypothermia should be considered in patients on these medications who present with non-specific symptoms. Regular monitoring of temperature and vital signs is crucial for early detection and management.

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