In situ MgO nanoparticle-doped Janus electrospun dressing against bacterial invasion and immune imbalance for irregular wound healing
Tao Zhou, Yedan Chen, Liangmin Fu, Shan Wang, Haihu Ding, Qiaosheng Bai, Jingjing Guan, Yingji Mao
TL;DR
A new wound dressing made with nanofibers and magnesium oxide nanoparticles helps fight infections and boost healing in irregular wounds.
Contribution
A Janus electrospun scaffold with MgO nanoparticles is developed to address bacterial invasion and immune imbalance in wound healing.
Findings
The PPGM scaffold effectively blocks bacterial colonization and maintains stability on wounds.
The scaffold promotes anti-inflammatory effects and accelerates vascularization and epithelialization.
The bilayer structure modulates collagen deposition and the inflammatory microenvironment.
Abstract
Owing to the unpredictable size of wounds and irregular edges formed by trauma, nanofibers’ highly customizable and adherent in situ deposition can contribute to intervention in the healing process. However, electrospinning is limited by the constraints of conventional polymeric materials despite its potential for anti-inflammatory and antimicrobial properties. Here, inspired by the Janus structure and biochemistry of nanometal ions, we developed an in situ sprayed electrospinning method to overcome bacterial infections and immune imbalances during wound healing. The bilayer fiber scaffold has a hydrophobic outer layer composed of polycaprolactone (PCL) and a hydrophilic inner layer composed of gelatin, poly(L-lactic acid) (PLLA), and magnesium oxide nanoparticles, constituting the PCL/PLLA-gelatin-MgO (PPGM) electrospun scaffold. This electrospun scaffold blocked the colonization and…
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Taxonomy
TopicsNuclear Engineering Thermal-Hydraulics · Nuclear reactor physics and engineering · Nuclear Materials and Properties