# Intraoperative Transient Central Diabetes Insipidus Status Post-Cerebellopontine Meningioma Resection: A Case Report

## TL;DR

A patient developed central diabetes insipidus after a brain tumor surgery, highlighting the need for careful drug selection during such procedures.

## Contribution

The paper reports a case of transient central diabetes insipidus following cerebellopontine meningioma resection and discusses anesthetic drug associations.

## Key findings

- The patient produced 8650 mL of urine with low specific gravity despite vasopressin therapy.
- Anesthetic drugs like alpha-2 agonists and sevoflurane are linked to increased CDI incidence.
- Desmopressin is recommended over vasopressin for longer neurosurgical procedures.

## Abstract

Central diabetes insipidus (CDI) is a neurological pathological condition in which vasopressin synthesis has been compromised. A 52-year-old male presented with a cerebellopontine angle mass not involving the hypothalamic-pituitary axis. Despite vasopressin therapy, the patient produced a total of 8650 mL of urine, with the urine-specific gravity measured at 1.002 near hour 8. A literature review found associations with certain anesthetic drugs that have an increased incidence of CDI, including alpha-2 agonists and sevoflurane. Reports have recommended administering desmopressin over vasopressin, especially for neurosurgery cases that warrant a more extended operative period, given that desmopressin has a longer context-sensitive half-life.