# Innovative Management of Opioid-Induced Hyperalgesia Using Lidocaine Infusion: A Case Report

**Authors:** Andrei Bautista, Ryan Ferguson, Praveen Reddy Elmati, Alexander Bautista

PMC · DOI: 10.7759/cureus.66376 · 2024-08-07

## TL;DR

This case report explores using lidocaine infusion to manage opioid-induced hyperalgesia, a condition where pain sensitivity increases due to long-term opioid use.

## Contribution

The paper introduces a novel treatment approach combining lidocaine and morphine for managing opioid-induced hyperalgesia.

## Key findings

- Lidocaine infusion showed promise in mitigating opioid-induced hyperalgesia effects.
- Combining lidocaine with morphine may offer a viable treatment strategy for OIH patients.
- Further research is needed to confirm the treatment's efficacy and safety.

## Abstract

Prolonged opioid use carries risks, including addiction and dependence. A significant consequence of chronic opioid use is opioid-induced hyperalgesia (OIH), where patients experience heightened pain sensitivity. Managing OIH typically involves reducing opioid intake while mitigating withdrawal symptoms. This case report presents a patient with OIH treated with intravenous lidocaine and morphine. OIH presents complex pain management challenges, and lidocaine infusion has shown promise in mitigating its effects. Further research is needed to comprehensively assess the efficacy and safety of this treatment approach for patients with OIH.

## Linked entities

- **Chemicals:** lidocaine (PubChem CID 3676), morphine (PubChem CID 5288826)

## Full-text entities

- **Diseases:** pain (MESH:D010146), Hyperalgesia (MESH:D006930), addiction (MESH:D019966), withdrawal symptoms (MESH:D013375)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC11378742