# Contact lens fitting and changes in the tear film dynamics: mathematical and computational models review

**Authors:** Darshan Ramasubramanian, José Luis Hernández-Verdejo, José Manuel López-Alonso

PMC · DOI: 10.1007/s00417-024-06400-5 · 2024-03-02

## TL;DR

This paper reviews mathematical and computational models to better understand tear film dynamics and improve contact lens fitting and ocular health.

## Contribution

The paper provides a comprehensive review of mathematical and computational models for tear film dynamics and contact lens wear, emphasizing interdisciplinary approaches.

## Key findings

- Mathematical models offer insights into tear film dynamics but are limited by simplifications.
- Computational mechanical models integrate tear film dynamics into a Multiphysics framework to study eye biomechanics.
- Non-invasive diagnostic tools like OCT and thermal imaging help customize Multiphysics models for contact lens wearers.

## Abstract

This review explores mathematical models, blinking characterization, and non-invasive techniques to enhance understanding and refine clinical interventions for ocular conditions, particularly for contact lens wear.

The review evaluates mathematical models in tear film dynamics and their limitations, discusses contact lens wear models, and highlights computational mechanical models. It also explores computational techniques, customization of models based on individual blinking dynamics, and non-invasive diagnostic tools like high-speed cameras and advanced imaging technologies.

Mathematical models provide insights into tear film dynamics but face challenges due to simplifications. Contact lens wear models reveal complex ocular physiology and design aspects, aiding in lens development. Computational mechanical models explore eye biomechanics, often integrating tear film dynamics into a Multiphysics framework. While different computational techniques have their advantages and disadvantages, non-invasive tools like OCT and thermal imaging play a crucial role in customizing these Multiphysics models, particularly for contact lens wearers.

Recent advancements in mathematical modeling and non-invasive tools have revolutionized ocular health research, enabling personalized approaches. The review underscores the importance of interdisciplinary exploration in the Multiphysics approach involving tear film dynamics and biomechanics for contact lens wearers, promoting advancements in eye care and broader ocular health research.

## Full-text entities

- **Genes:** mucin [NCBI Gene 100508689]
- **Diseases:** vision impairment (MESH:D014786), DED (MESH:D015352), keratoconus (MESH:D007640), inflammatory (MESH:D007249), blinks (MESH:D000092164), TBUT (MESH:D000377), DE (MESH:D003635), CL (MESH:D007905), ocular discomfort (MESH:D015817)
- **Chemicals:** oil (MESH:D009821), lipid (MESH:D008055), CLs (MESH:D002713), fluorescein (MESH:D019793), water (MESH:D014867)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11377471/full.md

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Source: https://tomesphere.com/paper/PMC11377471