Active template synthesis
Romain Jamagne, Martin J. Power, Zhi-Hui Zhang, Germán Zango, Benjamin Gibber, David A. Leigh
TL;DR
Active template synthesis is a method to build complex interlocked molecules using metals or functional groups as both templates and catalysts.
Contribution
This review highlights the use of active template synthesis for creating interlocked molecules without leaving behind template interactions.
Findings
Active template synthesis allows for the creation of rotaxanes, catenanes, and knots under kinetic control.
Metal-free versions use crown ethers to accelerate reactions for building rotaxanes without recognition elements.
The CuAAC reaction is the most widely used in metal-mediated active template synthesis.
Abstract
The active template synthesis of mechanically interlocked molecular architectures exploits the dual ability of various structural elements (metals or, in the case of metal-free active template synthesis, particular arrangements of functional groups) to serve as both a template for the organisation of building blocks and as a catalyst to facilitate the formation of covalent bonds between them. This enables the entwined or threaded intermediate structure to be covalently captured under kinetic control. Unlike classical passive template synthesis, the intercomponent interactions transiently used to promote the assembly typically do not ‘live on’ in the interlocked product, meaning that active template synthesis can be traceless and used for constructing mechanically interlocked molecules that do not feature strong binding interactions between the components. Since its introduction in 2006,…
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Taxonomy
Topicssemigroups and automata theory · Advanced Algebra and Logic · Natural Language Processing Techniques