# Isolated Adrenocorticotropic Hormone Deficiency Diagnosed After the Cessation of Glucocorticoid Therapy for Eosinophilic Esophagitis: A Case Report

## TL;DR

A 71-year-old woman developed adrenal insufficiency after stopping glucocorticoid therapy, and doctors diagnosed her with a rare pituitary disorder instead of a reversible condition.

## Contribution

This case highlights the importance of distinguishing isolated adrenocorticotropic hormone deficiency from glucocorticoid-induced adrenal insufficiency.

## Key findings

- The patient's adrenal insufficiency was caused by isolated adrenocorticotropic hormone deficiency, not by GC-induced secondary adrenal insufficiency.
- The case emphasizes the need for endocrinological evaluation when adrenal symptoms arise after GC therapy reduction.
- The patient required lifelong hydrocortisone replacement therapy.

## Abstract

Isolated adrenocorticotropic hormone deficiency (IAD) is a rare pituitary disorder that can cause adrenal insufficiency. However, due to its nonspecific symptoms, its diagnosis is often difficult and may be delayed. Patients with IAD require lifelong glucocorticoid (GC) replacement therapy. Contrastingly, GC-induced secondary adrenal insufficiency is a reversible condition that arises when patients receiving GC therapy reduce their GC dosage or discontinue therapy. Differentiating between IAD and GC-induced secondary adrenal insufficiency is clinically crucial. We report a unique case that required differentiation between these two conditions.

A 71-year-old Japanese woman presented with symptoms of adrenal insufficiency after discontinuation of GC therapy for eosinophilic esophagitis. We conducted detailed interviews and repeated the endocrinological examinations. We concluded that her symptoms were owing to IAD rather than GC-induced secondary adrenal insufficiency.

She began a lifelong hydrocortisone replacement therapy. This case suggests that when caring for patients undergoing GC therapy, it is important to consider the possibility of coexisting IAD and arrange endocrinological examinations if signs of adrenal insufficiency arise during the gradual reduction of GC treatment.