# Biological Abnormalities of Hemostasis in Patients with Epistaxis or Menorrhagia in Yaoundé, Cameroon

## TL;DR

This study in Cameroon found that epistaxis and menorrhagia are often linked to primary hemostasis issues, with many patients showing abnormal blood clotting parameters.

## Contribution

The study provides new insights into the prevalence and biological causes of bleeding disorders in Cameroon.

## Key findings

- 60% of patients had at least one abnormal hemostasis parameter.
- Low von Willebrand factor was the most common abnormality (30.19%).
- Primary hemostasis abnormalities were the main cause of bleeding disorders in the study population.

## Abstract

In Cameroon, screening and diagnosis of minor hemorrhagic syndromes remain difficult and few research studies have been done to assess the magnitude of future bleeding risk and the burden of these disorders on quality of life. Epistaxis and menorrhagia are the two leading causes of bleeding disorders in the world population.

The aim of this study was to investigate the biological abnormalities of hemostasis in patients with epistaxis and menorrhagia.

From January to December 2021, we conducted a cross-sectional study in six hospitals with a gynecology and ENT department. We selected patients who presented epistasis or menorrhagia through clinical file and made them pass an interview and biological exams. Venous blood collected on EDTA tube allowed us to measure full blood count, thin blood smear, and blood grouping. PT, APPT, and fibrinogen assay were measured from citrate platelet-poor plasma. This plasma stored at −20°C for a maximum of 3 months allowed us to measure vWF : Ag and vWF : CBA ELISA. The bleeding time was measured at the time of sampling.

In total, our study population consisted of 60 patients aged 01–45 years. Epistaxis (40%) and menorrhagia (29%) were the two main causes of bleeding complaints in our study, in addition to gingivorrhagia (15%) and prolonged bleeding after injury (03%). Almost 60% of the population had at least one abnormal hemostasis parameter. The main abnormalities found were low von Willebrand factor (30.19%), presence of macroplatelets (16.98%), prolonged bleeding time (15.09%), prolonged PT (15.09%), and low platelet count (¬07.55%).

In Cameroon, bleeding disorders manifested by epistaxis and menorrhagia are mainly caused by abnormalities of primary hemostasis.