A biophysical minimal model to investigate age-related changes in CA1 pyramidal cell electrical activity
Erin C. McKiernan, Marco A. Herrera-Valdez, Diano F. Marrone, Jordi Garcia-Ojalvo, Jordi Garcia-Ojalvo, Jordi Garcia-Ojalvo
TL;DR
This paper introduces a biophysical model to study how aging affects the electrical activity of brain cells, specifically in the hippocampus.
Contribution
The paper presents a novel minimal biophysical model of CA1 pyramidal cells to investigate age-related changes in their electrical activity.
Findings
The model reproduces variability in electrical activity seen in CA1 pyramidal cells by adjusting ion channel parameters.
Increased L-type Ca2+ channel expression in the model mimics age-related changes observed in aged animals.
The model predicts new age-related changes in PC bursting activity not previously reported.
Abstract
Aging is a physiological process that is still poorly understood, especially with respect to effects on the brain. There are open questions about aging that are difficult to answer with an experimental approach. Underlying challenges include the difficulty of recording in vivo single cell and network activity simultaneously with submillisecond resolution, and brain compensatory mechanisms triggered by genetic, pharmacologic, or behavioral manipulations. Mathematical modeling can help address some of these questions by allowing us to fix parameters that cannot be controlled experimentally and investigate neural activity under different conditions. We present a biophysical minimal model of CA1 pyramidal cells (PCs) based on general expressions for transmembrane ion transport derived from thermodynamical principles. The model allows directly varying the contribution of ion channels by…
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Taxonomy
TopicsNeural dynamics and brain function · stochastic dynamics and bifurcation · Neuroscience and Neuropharmacology Research