# Degenerative Atypia in Clival Chordoma: Two Case Reports

## TL;DR

This paper presents two cases of chordoma treated with surgery and radiation, showing different effects based on radiation type.

## Contribution

The study highlights the effectiveness of carbon ion therapy in controlling chordoma with fewer side effects.

## Key findings

- Carbon ion therapy leads to necrosis and fibrosclerosis in chordoma.
- Classical radiation results in cellular atypia and fibrosis.
- Carbon ion therapy may offer better tumor control with minimal side effects.

## Abstract

In this study, we report surgical management combined with radiotherapy in two patients with typical chordoma. Different types of radiation have varied effects on chordomas when they are radiated. Classical cases display cellular atypia and fibrosis following irradiation, while necrosis and fibrosclerosis are observed after carbon ion therapy, implying that it is possible to control the tumor more effectively using carbon ion therapy with minimal side effects.