Successful Treatment of Peripheral Nerve Sheath Tumor-related Pain with Perineural Steroid Injection: a case report

TL;DR

A young NF1 patient experienced successful pain relief from a steroid injection for a nerve tumor, offering a new treatment option.

Contribution

This case report demonstrates the effectiveness of perineural steroid injections for NF1-related nerve tumor pain.

Findings

Ultrasound-guided perineural steroid injection relieved sciatic nerve compression in an NF1 patient.

Steroid injections offer a non-surgical alternative for managing NF1-related pain.

The treatment provided symptomatic relief when other conservative methods failed.

Abstract

Pain associated with Neurofibromatosis Type 1 (NF1) is poorly understood. To date, no treatment options have been approved for NF1-related pain. We present the case of a young female NF1 patient with intermittent buttock pain radiating down the leg who presented with positive dural tension signs. The patient was diagnosed with neurofibroma sciatic nerve compression, which was successfully managed with ultrasound-guided perineural steroid injection. There is sparse literature regarding the efficacy of ultrasound-guided perineural steroid injection in NF1 patients for treatment of benign peripheral nerve sheath tumor compressions. This case describes the utility of perineural steroid injections for symptomatic relief of NF1 neurofibroma-related pain. Perineural steroid injections should be considered when neurofibroma-related pain fails to respond to other conservative treatment. Steroid injections provide an alternative to oral medicinal management and avoid the often morbid risks of surgical intervention.

Figures