# Causes, risk factors, and complications of accidental intra-arterial administration of medications in a children’s hospital: a case series

## TL;DR

This study reports 10 cases of accidental intra-arterial medication administration in children and highlights risk factors and prevention strategies.

## Contribution

The paper presents a case series from a single pediatric hospital, identifying common sites and risk factors for accidental arterial medication administration.

## Key findings

- Accidental arterial cannulation commonly occurred in the dorsum of the foot and hand.
- Difficult IV access was associated with unintentional arterial cannulation.
- No serious adverse events were reported despite delayed detection in some cases.

## Abstract

Accidental intra-arterial administration of a medication can lead to serious iatrogenic harm. Most studies have discussed single cases of accidental intra-arterial administration of a medication, but only a few have described multiple cases occurring in a single, pediatric hospital setting.

The subjects were pediatric patients with an accidental intra-arterial administration of a medication. After obtaining approval from the institutional review board, the relevant cases were extracted from incident reports submitted to the patient safety office of the study center between November 2016 and April 2023.

A review of 18,204 incident reports yielded 10 cases (patient age: 27 days to 13 years) of accidental intra-arterial administration of a medication. The most common site of the cannulation was the dorsum of the foot followed by the dorsum of the hand. The medications administered were narcotics, sedatives, muscle relaxants, antibiotics, and crystalloids. No serious adverse events occurred after injection. In some cases, the accidental arterial cannulation was not discovered immediately (53 min to 26 days). Seven patients had difficult intravenous access; in two of these, ultrasound-guided peripheral venous cannulation was used.

We experienced 10 cases of accidental intra-arterial administration of a medication. The dorsalis pedis artery and the radial artery around the anatomical tobacco socket were common sites of unintentional arterial cannulation. Difficult intravenous (IV) access may be associated with unintentional arterial cannulation. If IV access is difficult or the free IV drip is sluggish, strict vigilance and repeated confirmation are needed to prevent unintentional arterial cannulation.