# Case report: A case of giant breast skin warts caused by HPV infection

## TL;DR

This case report describes a rare instance of a large breast wart caused by HPV that developed into skin cancer.

## Contribution

The novelty lies in documenting a rare case of HPV-induced giant breast skin warts progressing to squamous cell carcinoma.

## Key findings

- A giant wart on the breast skin was caused by HPV infection.
- The wart progressed to cutaneous squamous cell carcinoma.
- HPV types 6 and 111 are associated with this rare condition.

## Abstract

GCA, also known as Buschke-Lowenstein tumor, is a rare sexually transmitted disease associated with HPV types 6 and 111. These warts are considered histologically benign, but there is a risk of localized invasion and development of malignancy. This malignant transformation occurs most often in the perianal and vulvar areas, and involvement of other sites is relatively rare2. In this case, we report a rare case of a giant wart originating from breast skin infected with HPV and progressing to cutaneous squamous cell carcinoma.