# Deranged Liver Function Tests Associated With Hyperferritinemia in a Patient With Type 2 Diabetes Mellitus: A Case Study and Literature Review

**Authors:** Erwa Eltayib Elmakki

PMC · DOI: 10.7759/cureus.66074 · Cureus · 2024-08-03

## TL;DR

A patient with type 2 diabetes showed abnormal liver tests and high iron levels, highlighting the link between diabetes, liver disease, and iron metabolism.

## Contribution

This case study emphasizes the need to monitor liver and iron metabolism in T2DM patients.

## Key findings

- A T2DM patient presented with elevated liver enzymes and hyperferritinemia.
- The patient was diagnosed with MASH and dysregulated iron metabolism.
- The case underscores the complex relationship between diabetes, liver disease, and cardiovascular risk.

## Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common complication in patients with type 2 diabetes mellitus (T2DM), potentially progressing to more severe conditions such as metabolic dysfunction-associated steatohepatitis (MASH), liver cirrhosis, and hepatocellular carcinoma. This case study presents a 55-year-old man with long-standing T2DM who was found to have deranged liver function tests, elevated serum iron, and hyperferritinemia during a routine follow-up visit. The patient's clinical presentation, laboratory findings, and imaging results led to a diagnosis of MASH, complicated by dysregulated iron metabolism. This case highlights the importance of vigilant monitoring of liver function and iron studies in T2DM patients. Furthermore, it illustrates the challenges in managing the complex interplay between metabolic syndrome, liver dysfunction, and cardiovascular risk.

## Linked entities

- **Diseases:** type 2 diabetes mellitus (MONDO:0005148), metabolic dysfunction-associated steatotic liver disease (MONDO:0013209), metabolic dysfunction-associated steatohepatitis (MONDO:0007027), hepatocellular carcinoma (MONDO:0007256)

## Full-text entities

- **Diseases:** hepatocellular carcinoma (MESH:D006528), liver cirrhosis (MESH:D008103), Hyperferritinemia (MESH:D000085583), MASLD (MESH:D008107), metabolic syndrome (MESH:D024821), MASH (MESH:D005234), Deranged Liver (MESH:D017093), T2DM (MESH:D003924)
- **Chemicals:** iron (MESH:D007501)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC11368582/full.md

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Source: https://tomesphere.com/paper/PMC11368582