# Disseminated Mycobacterium avium Complex Infection Following CD3/CD20 Bispecific Antibody Therapy in a Patient With Follicular Lymphoma

**Authors:** Jessica S Little, Rocio M Hurtado, Nicholas Boire, Lindsey R Baden, Alvaro C Laga, Ann W Silk, Caron A Jacobson

PMC · DOI: 10.1093/ofid/ofae460 · Open Forum Infectious Diseases · 2024-08-08

## TL;DR

A patient with follicular lymphoma developed a rare infection after receiving a new type of antibody therapy.

## Contribution

This is the first well-documented case of disseminated Mycobacterium avium complex following bispecific antibody therapy.

## Key findings

- Disseminated Mycobacterium avium complex infection occurred in a patient undergoing CD3/CD20 bispecific antibody therapy.
- Such opportunistic infections are rare but significant in patients receiving bispecific antibody treatments.

## Abstract

Infections remain a major concern following bispecific antibody therapy but are not well described in pivotal trials. We present the first well-documented case of a classic but rare opportunistic infection, disseminated Mycobacterium avium complex, in a patient receiving bispecific antibody therapy.

## Linked entities

- **Diseases:** follicular lymphoma (MONDO:0018906)

## Full-text entities

- **Genes:** KRT20 (keratin 20) [NCBI Gene 54474] {aka CD20, CK-20, CK20, K20, KRT21}
- **Diseases:** Follicular Lymphoma (MESH:D008224), opportunistic infection (MESH:D009894), Infections (MESH:D007239), Mycobacterium avium Complex Infection (MESH:D015270)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mycobacterium avium complex sp. (species) [taxon 37162]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11368541/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC11368541/full.md

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Source: https://tomesphere.com/paper/PMC11368541