# A Rare Case of a Heterotopic Sacrococcygeal Glial Nodule

**Authors:** William Moore, Siya N Setty, Allan E Stolarski, Christopher Muratore, Nayana Somayaji

PMC · DOI: 10.7759/cureus.66085 · Cureus · 2024-08-03

## TL;DR

This paper reports a rare case of a glial nodule in the sacrococcygeal area, highlighting its diagnostic importance despite being uncommon and hard to detect.

## Contribution

The paper contributes a rare clinical case of a sacrococcygeal heterotopic glial nodule and emphasizes its diagnostic significance.

## Key findings

- Heterotopic glial nodule was identified in the sacrococcygeal region through histopathology.
- The lesion intensely stained with glial fibrillary acidic protein and S-100.
- The case underscores the need to consider this rare condition in differential diagnosis despite nonspecific imaging findings.

## Abstract

Heterotopic glial nodule is a rare congenital non-neoplastic lesion that is characterized by ectopic brain tissue. It has occasionally been reported to affect areas such as the nose and face. The report presents a rare case of sacrococcygeal heterotopic glial nodule. Although teratomas are the most common neoplasms in this region, clinicians and radiologists should consider heterotopic glial nodule as a differential diagnosis, despite rarity and nonspecific imaging findings. Histopathology plays a crucial role in diagnosis, which intensely stains with glial fibrillary acidic protein and S-100.

## Linked entities

- **Proteins:** S100A1 (S100 calcium binding protein A1)

## Full-text entities

- **Genes:** S100A1 (S100 calcium binding protein A1) [NCBI Gene 6271] {aka S100, S100-alpha, S100A}, GFAP (glial fibrillary acidic protein) [NCBI Gene 2670] {aka ALXDRD}
- **Diseases:** Heterotopic glial nodule (MESH:D063192), Glial Nodule (MESH:D004194), ectopic brain tissue (MESH:D002828), teratomas (MESH:D013724), congenital non-neoplastic lesion (MESH:D020914), neoplasms (MESH:D009369)

## Full text

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## Figures

8 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11368173/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC11368173/full.md

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Source: https://tomesphere.com/paper/PMC11368173