# The prognostic significance of lncRNA FGD5-AS1 in various malignancies: a meta-analysis

## TL;DR

This study finds that high levels of the long non-coding RNA FGD5-AS1 are linked to worse cancer outcomes, suggesting it could be a useful biomarker for predicting prognosis.

## Contribution

This is the first meta-analysis to evaluate FGD5-AS1 as a prognostic biomarker across multiple cancer types.

## Key findings

- High FGD5-AS1 expression correlates with poor overall survival in various cancers.
- FGD5-AS1 is significantly associated with advanced tumor stage and lymph node metastasis.
- The RNA is upregulated in six cancer types according to GEPIA database analysis.

## Abstract

Cancer is widely recognized as a prominent contributor to global mortality due to factors such as delayed diagnosis, unfavorable prognosis, and high likelihood of recurrence. FGD5 transcription factor G antisense RNA 1(FGD5-AS1), a newly identified long non-coding RNA, has emerged as a promising prognostic biomarker, for malignancy prognosis. This meta-analysis aimed to assess the prognostic significance of FGD5-AS1 in various carcinomas.

A systematic search was performed through five electronic databases to identify studies that investigating the role of FGD5-AS1 expression as a prognostic factor in carcinomas. The value of FGD5-AS1 in malignancies was estimated by odds ratios (ORs) and hazard ratios (HRs) with a corresponding 95% confidence intervals (CIs). Furthermore, the GEPIA database was used to further supplement our results.

This analysis included 12 studies with 642 cases covering eight cancer types. High FGD5-AS1 expression exhibited a significant correlation with poor overall survival(OS) (HR = 2.04, 95%CI [1.72, 2.42], P < 0.00001), advanced tumor stage (OR = 3.47, 95%CI [2.34, 5.14], P < 0.00001), lymph node metastasis(LNM) (OR = 1.79, 95% CI [1.20,2.67], P = 0.004), and larger tumor size (OR= 5.25, 95%CI [2.68, 10.30], P < 0.00001). Furthermore, the FGD5-AS1 expression was notably upregulated in six types of malignancies as verified using the GEPIA online gene analysis tool.

The findings of this meta-analysis indicated that high FGD5-AS1 expression was significantly associated with poor prognosis in diverse cancer types, suggesting that FGD5-AS1 may be a promising biomarker for predicting cancer prognosis.

https://www.york.ac.uk/inst/crd, identifier CRD42024552582.