# Changes in Physical Fitness, Muscle Damage and Cognitive Function in Elite Rugby Players over a Season

**Authors:** Mohamed Houssem Karamti, Hassane Zouhal, Mariem Bousselmi, Manel Darragi, Hamdi Khannous, Ahlem Ben Hmid, Imen Zamali, Mélika Ben Ahmed, Ismail Laher, Urs Granacher, Amira Zouita Ben Moussa

PMC · DOI: 10.3390/sports12080223 · 2024-08-16

## TL;DR

This study tracks how elite rugby players' physical fitness, muscle damage, and cognitive markers change over a season.

## Contribution

The study provides new insights into how physical load affects muscle damage and cognitive markers in elite rugby players based on their position.

## Key findings

- Backs showed better performance improvements than forwards in most physical tests.
- Muscle damage markers decreased in forwards but increased in LDH for backs by the end of the season.
- BDNF levels decreased in the total group between the second and third sampling periods.

## Abstract

This study proposes to monitor the physical, immune and cognitive responses and adaptations of elite rugby players throughout the season based on the loads performed. Anthropometric measurements, physical fitness tests (e.g., muscle strength and power, linear and change-of-direction speed, cardiorespiratory fitness) and analyses of serum concentrations of markers of muscle damage (creatine kinase [CK] and lactate dehydrogenase [LDH]) and brain-derived neurotrophic factor (BDNF) were carried out over a sporting season (24 weeks) for 17 elite rugby players (10 forwards and 7 backs) aged 18.91 ± 0.76 years. The physical fitness test results show improvements in the performance of both forwards and backs over the season (p < 0.05), with an advantage for backs compared with forwards in most tests (p < 0.05). Muscle damage markers decreased at the end of the season compared with the baseline levels for forwards (p < 0.05). CK levels were unchanged for the backs, but there were increased LDH concentrations at the end of the season compared with baseline (p < 0.05). Serum BDNF levels decreased for the total group between the second and third sampling (p < 0.05). The muscular and physical capacities of rugby players differ according to their playing position. Immune responses and adaptations, as well as BDNF levels, vary throughout the season and depend on the physical load performed.

## Full-text entities

- **Genes:** BDNF (brain derived neurotrophic factor) [NCBI Gene 627] {aka ANON2, BULN2}, CMPK1 (cytidine/uridine monophosphate kinase 1) [NCBI Gene 51727] {aka CK, CMK, CMPK, UMK, UMP-CMPK, UMPK}
- **Diseases:** Function (MESH:D003291), Muscle Damage (MESH:D009133)

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11360730/full.md

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Source: https://tomesphere.com/paper/PMC11360730