# Comment on Utsumi et al. Differences in Pathophysiology and Treatment Efficacy Based on Heterogeneous Out-of-Hospital Cardiac Arrest. Medicina 2024, 60, 510

## TL;DR

This comment paper addresses inaccuracies in a review on out-of-hospital cardiac arrest, focusing on NSE thresholds and reference errors.

## Contribution

The paper clarifies threshold values for neuron-specific enolase and corrects misquoted references in Utsumi et al.'s work.

## Key findings

- Threshold values for neuron-specific enolase differ based on initial cardiac arrest rhythm.
- Several references in the original article were misquoted or incorrectly cited.
- Correcting these issues improves the accuracy of OHCA pathophysiology and treatment interpretations.

## Abstract

We read with great interest the review article on pathophysiology and treatment based on different out-of-hospital cardiac arrest (OHCA) patients. We wish to present our comments on the threshold values for neuron-specific enolase (NSE) based on the initial rhythm and the misquoting of a few references in that article.