# Metaplastic Breast Carcinoma: A Rare Presentation in a Young Female With Double Hormone Receptor-Positive Tumor

**Authors:** Anas Al Rabadi, Ahmad Al Kofahi, Laith Albudour, Mansour Abushqair, Taher Harahsheh, Hend Al-harahsheh, Duaa Al-shurbaji

PMC · DOI: 10.7759/cureus.65674 · 2024-07-29

## TL;DR

A rare case of metaplastic breast cancer in a young woman with a double hormone receptor-positive tumor is reported, highlighting the importance of accurate diagnosis and treatment.

## Contribution

This paper presents a rare clinical case of metaplastic breast carcinoma in a young female with a double hormone receptor-positive tumor.

## Key findings

- A 31-year-old female was diagnosed with metaplastic breast carcinoma through immunohistochemistry.
- The tumor was double hormone receptor-positive, a rare presentation in MBC.
- The case emphasizes the need for accurate diagnosis and tailored treatment strategies for aggressive breast cancer subtypes.

## Abstract

Metaplastic breast carcinoma (MBC) represents a rare subtype of breast cancer, characterized by poor prognostic indicators that have been recently identified. Clinical and radiological presentations often mimic other breast cancer types, necessitating immunohistochemistry (IHC) for accurate diagnosis. In this study, we report a case involving a 31-year-old female presenting with a painless, fixed, non-inflammatory mass in the left breast, which was confirmed as MBC. Treatment encompassed lumpectomy, chemotherapy, radiotherapy, and subsequent hormonal therapy. Understanding this rarely reported yet aggressive form of breast cancer holds significant importance for clinicians, enabling them to promptly establish a diagnosis and implement effective management strategies.

## Linked entities

- **Diseases:** metaplastic breast carcinoma (MONDO:0006043), breast cancer (MONDO:0004989)

## Full-text entities

- **Genes:** NR4A1 (nuclear receptor subfamily 4 group A member 1) [NCBI Gene 3164] {aka GFRP1, HMR, N10, NAK-1, NGFIB, NP10}
- **Diseases:** Tumor (MESH:D009369), MBC (MESH:D001943), inflammatory (MESH:D007249)

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11355489/full.md

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Source: https://tomesphere.com/paper/PMC11355489