# Telomeres and SIRT1 as Biomarkers of Gamete Oxidative Stress, Fertility, and Potential IVF Outcome

## TL;DR

This review explores how telomeres and SIRT1 could serve as biomarkers for gamete quality and IVF success by protecting against oxidative stress.

## Contribution

The paper highlights the novel potential of SIRT1 and telomeres as biomarkers for fertility and IVF outcomes.

## Key findings

- Oxidative stress damages telomeres and affects gamete quality.
- SIRT1 may protect against oxidative stress and maintain genome stability.
- Telomeres and SIRT1 could predict assisted reproduction technique outcomes.

## Abstract

The number of infertile couples undergoing in vitro fertilisation (IVF) has increased significantly. The efficacy of this procedure is contingent upon a multitude of factors, including gamete quality. One factor influencing gamete quality is oxidative stress, which leads to telomere damage and accelerates cellular ageing. Identifying new biomarkers that can predict the success of assisted reproduction techniques is a current relevant area of research. In this review, we discuss the potential role of SIRT1, a protein known to protect against oxidative stress and telomeres, which are responsible for genome stability, as biomarkers of gamete quality and assisted reproduction technique outcomes.